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KMID : 0360419940300030337
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Korean Journal of Pharmacology
1994 Volume.30 No. 3 p.337 ~ p.342
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Losartan Modifies Nitric Oxide-related Vasorelaxation in Isolated Aorta of Spontaneously Hypertensive Rat
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Park Bong-Gee
Han Hyung-Soo
Kim Choong-Young
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Abstract
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It is well known that angiotensin converting enzyme inhibitors(ACEIs) increase endothelium-dependent relaxation in aortic strips of spontaneously hypertensive rats(SHR) and this increase in relaxation may be due to altered endothelial nitric oxide breakdown. But there are few studies on the effect of the angiotensin II receptor blocker on the nitric oxide-mediated relaxation. So we attempted to investigate the effect of angiotensin II receptor blocker on the nitric oxide-dependent relaxation in isolated aorta of SHR. Two week-treatment of losartan (30 mg/kg/day) increased the acetylcholine-and histamine-induced relaxation in endothelium intact strips but 90 minutes-treatment of losartan showed no increase in relaxation. The phenylephrine -induced contraction, repeated every 2 hours, was diminished gradually following lipopolysaccharide (LPS)-treatment but there was no significant difference in enalapril- and losartan-treated group compared with control group. These results suggest that activity of the endothelial constitutive NO synthase may be changed by chronic treatment of angiotensin II receptor blockers and ACEIs but angiotensin II antagonist and ACEI have no effect on the inducible NO synthase activity in the isolated aorta of SHR
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KEYWORD
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Nitric oxide, Losartan, SHR, Lipopolysaccharide, LNMMA, Aorta
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